Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLS | O94925 | 5/20 | 0.44 |
| ▸ | KDR | P35968 | 6/20 | 0.43 |
| ▸ | FGFR3 | P22607 | 6/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | STAT3 | P40763 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3381810 | 0.86 | CCNE1 (0.48) | KDRFGFR3SMN1; SMN2 | |
| SCHEMBL3196061 | 0.86 | KDR (0.46) | KDRFGFR3 | |
| SCHEMBL3384404 | 0.85 | KDR (0.42) | KDRFGFR3 | |
| SCHEMBL3195990 | 0.84 | KDR (0.42) | KDRFGFR3 | |
| SCHEMBL3384151 | 0.83 | KDR (0.44) | KDRFGFR3 | |
| SCHEMBL3196212 | 0.81 | KDR (0.46) | KDRFGFR3 | |
| SCHEMBL3385506 | 0.81 | KDR (0.44) | KDRFGFR3SMN1; SMN2 | |
| SCHEMBL3380938 | 0.81 | KDR (0.46) | KDRFGFR3 | |
| SCHEMBL3379579 | 0.81 | KDR (0.43) | KDRFGFR3SMN1; SMN2 | |
| SCHEMBL3384308 | 0.81 | KDR (0.47) | KDRFGFR3SMN1; SMN2POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101128461-B | Imidazo (1, 2-a) pyridine compounds as VEGF-R2 inhibitors | LILLY CO ELI | 2010-12-22 | — | — | CN | disclosed |
| EP-1904494-B1 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS VEGF-R2 INHIBITORS | LILLY CO ELI (US) | 2010-12-01 | — | — | EP | disclosed |
| CN-101128461-A | Imidazo (1, 2-a) pyridine compounds as VEGF-R2 inhibitors | LILLY CO ELI (US) | 2008-02-20 | — | — | CN | disclosed |