Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 6/20 | 0.47 |
| ▸ | FGFR3 | P22607 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | SLC27A1 | Q6PCB7 | 3/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3381810 | 0.82 | CCNE1 (0.48) | KDRFGFR3SMN1; SMN2 | |
| SCHEMBL3379579 | 0.82 | KDR (0.43) | KDRFGFR3SMN1; SMN2 | |
| SCHEMBL3185886 | 0.82 | FGFR3 (0.43) | KDRFGFR3WNT3A | |
| SCHEMBL3382858 | 0.81 | GLS (0.44) | KDRFGFR3SMN1; SMN2MEN1KMT2A | |
| SCHEMBL3196061 | 0.81 | KDR (0.46) | KDRFGFR3ALDH1A1 | |
| SCHEMBL3196212 | 0.81 | KDR (0.46) | KDRFGFR3 | |
| SCHEMBL3380938 | 0.81 | KDR (0.46) | KDRFGFR3 | |
| SCHEMBL3385506 | 0.81 | KDR (0.44) | KDRFGFR3ALDH1A1SMN1; SMN2WNT3A | |
| SCHEMBL3385376 | 0.81 | KDR (0.43) | KDRFGFR3 | |
| SCHEMBL3386462 | 0.80 | KDR (0.39) | KDRFGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904494-B1 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS VEGF-R2 INHIBITORS | LILLY CO ELI (US) | 2010-12-01 | — | — | EP | disclosed |