Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 12/20 | 0.43 |
| ▸ | FGFR3 | P22607 | 11/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 4/20 | 0.38 |
| ▸ | PRKACA | P17612 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3382693 | 0.92 | WNT3A (0.41) | KDRFGFR3SMN1; SMN2 | |
| SCHEMBL3384206 | 0.89 | KDR (0.45) | KDRFGFR3SMN1; SMN2 | |
| SCHEMBL3381810 | 0.85 | CCNE1 (0.48) | KDRFGFR3SMN1; SMN2FLT3 | |
| SCHEMBL3383608 | 0.84 | SMN1; SMN2 (0.34) | KDRFGFR3SMN1; SMN2 | |
| SCHEMBL3384404 | 0.84 | KDR (0.42) | KDRFGFR3FLT3PRKACAROCK1 | |
| SCHEMBL3196212 | 0.84 | KDR (0.46) | KDRFGFR3FLT3 | |
| SCHEMBL3380938 | 0.84 | KDR (0.46) | KDRFGFR3FLT3 | |
| SCHEMBL3385506 | 0.84 | KDR (0.44) | KDRFGFR3SMN1; SMN2FLT3 | |
| SCHEMBL3197245 | 0.83 | KDR (0.44) | KDRFGFR3FLT3PRKACAROCK1 | |
| SCHEMBL3195990 | 0.82 | KDR (0.42) | KDRFGFR3FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101128461-B | Imidazo (1, 2-a) pyridine compounds as VEGF-R2 inhibitors | LILLY CO ELI | 2010-12-22 | — | — | CN | disclosed |
| EP-1904494-B1 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS VEGF-R2 INHIBITORS | LILLY CO ELI (US) | 2010-12-01 | — | — | EP | disclosed |
| CN-101128461-A | Imidazo (1, 2-a) pyridine compounds as VEGF-R2 inhibitors | LILLY CO ELI (US) | 2008-02-20 | — | — | CN | disclosed |