⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7152778 | 0.80 | ALDH1A1 (0.45) | — | |
| SCHEMBL17826010 | 0.75 | HTR2A (0.43) | — | |
| SCHEMBL132630 | 0.71 | ALDH1A1 (0.55) | — | |
| SCHEMBL24726902 | 0.69 | ALDH1A1 (0.36) | — | |
| SCHEMBL20944787 | 0.69 | ALDH1A1 (0.36) | — | |
| Propene SCHEMBL3281811 | 0.69 | MEN1 (0.42) | — | |
| SCHEMBL7107668 | 0.69 | ALDH1A1 (0.52) | — | |
| SCHEMBL22113017 | 0.68 | KMT2A (0.50) | — | |
| SCHEMBL21045006 | 0.66 | ALDH1A1 (0.39) | — | |
| Ethylene SCHEMBL5397976 | 0.65 | MEN1 (0.53) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 87 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1636300-B1 | NANOPOROUS LAMINATES | DOW GLOBAL TECHNOLOGIES LLC (US) | 2015-12-23 | — | — | EP | claimed |
| EP-1851778-B1 | METHOD OF MAKING MULTILAYERED CONSTRUCTION FOR USE IN RESISTORS AND CAPACITORS | OAK MITSUI INC (US) | 2012-08-08 | — | — | EP | claimed |
| US-8809358-B2 | Use of IκB-kinase inhibitors in pain therapy | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2014-08-19 | — | — | US | disclosed |
| US-8552206-B2 | NF-κB inhibitors and uses thereof | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) | 2013-10-08 | — | — | US | disclosed |
| US-7858808-B2 | Multi-substituted imidazolines and method of use thereof | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) | 2010-12-28 | — | — | US | disclosed |
| US-20100204260-A1 | Multi-Substituted Imidazolines And Method Of Use Thereof | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY | 2010-08-12 | — | — | US | disclosed |
| US-7652056-B2 | Using 4-imidazoline carboxylic acid or ester; antiinflammatory agents; microbiocides; bactericides; antitumor agenst0 | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) | 2010-01-26 | — | — | US | disclosed |
| EP-0903353-B1 | Imidazolidine derivates, their preparation and use, and pharmaceutical compositions containing them | SANOFI AVENTIS DEUTSCHLAND (DE) | 2009-11-25 | — | — | EP | disclosed |
| US-20090275603-A1 | NF- kB Inhibitors And Uses Thereof | MICHIGAN STATE UNIVERSITY | 2009-11-05 | — | — | US | disclosed |
| EP-1261601-B1 | SUBSTITUTED INDOLES FOR MODULATING NFKB ACTIVITY | SANOFI AVENTIS DEUTSCHLAND (DE) | 2009-07-29 | — | — | EP | disclosed |
| EP-1534686-B1 | NF-KB INHIBITORS AND USES THEREOF | UNIV MICHIGAN STATE (US) | 2009-05-20 | — | — | EP | disclosed |
| EP-0903353-A1 | Imidazolidine derivates, their preparation and use, and pharmaceutical compositions containing them | Hoechst Marion Roussel Deutschland GmbH (DE) | 1999-03-24 | — | — | EP | disclosed |
| EP-0842945-A2 | Heterocycles as inhibitors of leukocyte adhesion and as antagonists of VLA-4 | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-05-20 | — | — | EP | disclosed |
| EP-0842943-A2 | 5-Ring heterocycles as inhibitors of leukocyte adhesion and as VLA-4 antagonists | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-05-20 | — | — | EP | disclosed |
| EP-0842944-A2 | Heterocycles as inhibitors of leukocyte adhesion and as antagonists of VLA-4 | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-05-20 | — | — | EP | disclosed |
| US-5681838-A | ALSO FOR SUPPRESSING CANCER CELL METASTASES AND BINDING OF OSTEOCLASTS TO BONE SURFACES | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-10-28 | — | — | US | disclosed |
| EP-0729460-A1 | SUBSTITUTED 5-RING HETEROCYCLES, THEIR PREPARATION AND THEIR USE | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-09-04 | — | — | EP | disclosed |
| EP-0680468-A1 | SUBSTITUTED AMINO COMPOUNDS, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF THROMBOCYTE AGGREGATION | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-11-08 | — | — | EP | disclosed |
| WO-1995014008-A1 | SUBSTITUTED 5-RING HETEROCYCLES, THEIR PREPARATION AND THEIR USE | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-05-26 | — | — | WO | disclosed |
| WO-1994017034-A1 | SUBSTITUTED AMINO COMPOUNDS, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF THROMBOCYTE AGGREGATION | CASSELLA AKTIENGESELLSCHAFT (DE) | 1994-08-04 | — | — | WO | disclosed |