Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 12/20 | 0.44 |
| ▸ | FGFR3 | P22607 | 12/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | WNT3A | P56704 | 1/20 | 0.37 |
| ▸ | CTSC | P53634 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3385600 | 0.93 | KDR (0.46) | KDRFGFR3NTRK1FLT3PIK3CA | |
| SCHEMBL3386120 | 0.88 | KDR (0.46) | KDRFGFR3NTRK1FLT3WNT3A | |
| SCHEMBL3382504 | 0.86 | KDR (0.47) | KDRFGFR3NTRK1FLT3PIK3CA | |
| SCHEMBL3385818 | 0.85 | KDR (0.49) | KDRFGFR3 | |
| SCHEMBL3385300 | 0.84 | KDR (0.44) | KDRFGFR3NTRK1FLT3PIK3CA | |
| SCHEMBL3384151 | 0.83 | KDR (0.44) | KDRFGFR3NTRK1FLT3CTSC | |
| SCHEMBL3385506 | 0.80 | KDR (0.44) | KDRFGFR3FLT3PIK3CAMTOR | |
| SCHEMBL3383110 | 0.80 | RET (0.48) | KDRFGFR3NTRK1FLT3KCNH2 | |
| SCHEMBL3189267 | 0.79 | KDR (0.45) | KDRFGFR3WNT3A | |
| SCHEMBL3386163 | 0.79 | WNT3A (0.42) | KDRFGFR3WNT3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101128461-B | Imidazo (1, 2-a) pyridine compounds as VEGF-R2 inhibitors | LILLY CO ELI | 2010-12-22 | — | — | CN | disclosed |
| EP-1904494-B1 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS VEGF-R2 INHIBITORS | LILLY CO ELI (US) | 2010-12-01 | — | — | EP | disclosed |
| CN-101128461-A | Imidazo (1, 2-a) pyridine compounds as VEGF-R2 inhibitors | LILLY CO ELI (US) | 2008-02-20 | — | — | CN | disclosed |