Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 10/20 | 0.49 |
| ▸ | CSF1R | P07333 | 3/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.48 |
| ▸ | KDR | P35968 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | RAF1 | P04049 | 4/20 | 0.46 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.45 |
| ▸ | RET | P07949 | 1/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.45 |
| ▸ | KIT | P10721 | 1/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.45 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.44 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.44 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3382976 | 0.89 | KDR (0.43) | FLT3CSF1RKDRRAF1RET | |
| SCHEMBL3386414 | 0.84 | RAF1 (0.58) | FLT3CSF1RMAPK14KDRMEN1 | |
| SCHEMBL3380805 | 0.82 | FLT3 (0.57) | FLT3CSF1RMAPK14KDRMEN1 | |
| SCHEMBL3383492 | 0.82 | FLT3 (0.50) | FLT3CSF1RMAPK14KDRMEN1 | |
| SCHEMBL3385510 | 0.82 | MAPK14 (0.48) | FLT3CSF1RMAPK14KDRMEN1 | |
| SCHEMBL3382975 | 0.82 | FLT3 (0.49) | FLT3CSF1RMAPK14KDRMEN1 | |
| SCHEMBL3385832 | 0.81 | FGFR3 (0.39) | FLT3MAPK14KDRMAPK13MAPK12 | |
| SCHEMBL3189927 | 0.81 | KDR (0.57) | FLT3CSF1RMAPK14KDRMEN1 | |
| SCHEMBL3197428 | 0.80 | FLT3 (0.47) | FLT3CSF1RMAPK14KDRMEN1 | |
| SCHEMBL3385682 | 0.80 | FLT3 (0.54) | FLT3CSF1RMAPK14KDRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904494-B1 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS VEGF-R2 INHIBITORS | LILLY CO ELI (US) | 2010-12-01 | — | — | EP | disclosed |