Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 4/20 | 0.53 |
| ▸ | CSF1R | P07333 | 2/20 | 0.53 |
| ▸ | KDR | P35968 | 2/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.53 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.53 |
| ▸ | CCDC6 | Q16204 | 1/20 | 0.53 |
| ▸ | FLT3 | P36888 | 8/20 | 0.46 |
| ▸ | KIT | P10721 | 6/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.44 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3385282 | 0.91 | KDR (0.45) | RETCSF1RKDRKCNH2NTRK1 | |
| SCHEMBL3383110 | 0.90 | RET (0.48) | RETCSF1RKDRKCNH2NTRK1 | |
| SCHEMBL3386505 | 0.88 | RET (0.65) | RETCSF1RKDRKCNH2NTRK1 | |
| SCHEMBL3383303 | 0.86 | NPC1 (0.52) | RETCSF1RKDRKCNH2NTRK1 | |
| SCHEMBL3189878 | 0.85 | KDR (0.49) | RETKDRFLT3KITFGFR3 | |
| SCHEMBL3381104 | 0.84 | KDR (0.55) | RETCSF1RKDRKCNH2NTRK1 | |
| SCHEMBL3385275 | 0.82 | KDR (0.51) | RETCSF1RKDRKCNH2NTRK1 | |
| SCHEMBL3383492 | 0.82 | FLT3 (0.50) | RETCSF1RKDRKCNH2NTRK1 | |
| SCHEMBL3383912 | 0.81 | KDR (0.51) | KDRFGFR3 | |
| SCHEMBL3383013 | 0.81 | RET (0.48) | RETCSF1RKDRKCNH2NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904494-B1 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS VEGF-R2 INHIBITORS | LILLY CO ELI (US) | 2010-12-01 | — | — | EP | disclosed |