Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 12/20 | 0.48 |
| ▸ | KDR | P35968 | 6/20 | 0.45 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.40 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.40 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3385973 | 0.87 | FLT3 (0.51) | FLT3KDRACVR1 | |
| SCHEMBL3385184 | 0.82 | FLT3 (0.49) | FLT3KDRPRMT5WDR77 | |
| SCHEMBL3385439 | 0.79 | FLT3 (0.53) | FLT3KDR | |
| SCHEMBL8997484 | 0.78 | HRH3 (0.45) | — | |
| SCHEMBL3385437 | 0.77 | KDR (0.69) | FLT3KDR | |
| SCHEMBL3385516 | 0.75 | FLT3 (0.38) | FLT3KDRACVR1 | |
| SCHEMBL3198674 | 0.75 | PRMT5 (0.57) | FLT3KDRPRMT5WDR77 | |
| SCHEMBL3197100 | 0.74 | FLT3 (0.61) | FLT3KDR | |
| SCHEMBL3379605 | 0.74 | KDR (0.67) | FLT3KDR | |
| SCHEMBL3384216 | 0.74 | KDR (0.53) | FLT3KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101128461-B | Imidazo (1, 2-a) pyridine compounds as VEGF-R2 inhibitors | LILLY CO ELI | 2010-12-22 | — | — | CN | disclosed |
| EP-1904494-B1 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS VEGF-R2 INHIBITORS | LILLY CO ELI (US) | 2010-12-01 | — | — | EP | disclosed |
| CN-101128461-A | Imidazo (1, 2-a) pyridine compounds as VEGF-R2 inhibitors | LILLY CO ELI (US) | 2008-02-20 | — | — | CN | disclosed |