Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 12/20 | 0.51 |
| ▸ | KDR | P35968 | 7/20 | 0.48 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3383185 | 0.87 | FLT3 (0.48) | FLT3KDRACVR1 | |
| SCHEMBL3385516 | 0.78 | FLT3 (0.38) | FLT3KDRACVR1 | |
| SCHEMBL17556214 | 0.76 | KDR (0.82) | FLT3KDR | |
| SCHEMBL22130302 | 0.76 | ALDH1A1 (0.42) | KDR | |
| SCHEMBL3186080 | 0.75 | KDR (0.74) | FLT3KDR | |
| SCHEMBL3382949 | 0.73 | FLT3 (0.58) | FLT3KDR | |
| SCHEMBL3178429 | 0.73 | KDR (0.53) | FLT3KDR | |
| SCHEMBL29845383 | 0.73 | KDR (0.50) | FLT3KDR | |
| SCHEMBL3385513 | 0.72 | FLT3 (0.61) | FLT3KDR | |
| SCHEMBL3383955 | 0.72 | KDR (0.51) | FLT3KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101128461-B | Imidazo (1, 2-a) pyridine compounds as VEGF-R2 inhibitors | LILLY CO ELI | 2010-12-22 | — | — | CN | disclosed |
| EP-1904494-B1 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS VEGF-R2 INHIBITORS | LILLY CO ELI (US) | 2010-12-01 | — | — | EP | disclosed |
| CN-101128461-A | Imidazo (1, 2-a) pyridine compounds as VEGF-R2 inhibitors | LILLY CO ELI (US) | 2008-02-20 | — | — | CN | disclosed |