Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 11/20 | 0.49 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.48 |
| ▸ | FLT3 | P36888 | 8/20 | 0.46 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.46 |
| ▸ | FLT1 | P17948 | 6/20 | 0.45 |
| ▸ | FLT4 | P35916 | 6/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.45 |
| ▸ | KIT | P10721 | 5/20 | 0.45 |
| ▸ | CSF1R | P07333 | 5/20 | 0.45 |
| ▸ | AURKA | O14965 | 4/20 | 0.45 |
| ▸ | PLK4 | O00444 | 3/20 | 0.45 |
| ▸ | NTRK2 | Q16620 | 3/20 | 0.45 |
| ▸ | MARK2 | Q7KZI7 | 3/20 | 0.45 |
| ▸ | LCK | P06239 | 3/20 | 0.45 |
| ▸ | RET | P07949 | 3/20 | 0.45 |
| ▸ | AXL | P30530 | 3/20 | 0.45 |
| ▸ | FRK | P42685 | 3/20 | 0.45 |
| ▸ | RPS6KA3 | P51812 | 3/20 | 0.45 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3386700 | 0.90 | KDR (0.48) | KDRMAP2K7FLT3MAP4K1FLT1 | |
| SCHEMBL3387734 | 0.88 | FLT3 (0.47) | KDRMAP2K7FLT3MAP4K1FLT1 | |
| SCHEMBL3386648 | 0.81 | KDR (0.52) | KDRFLT3FLT1FLT4ROCK2 | |
| SCHEMBL3387499 | 0.80 | CNR1 (0.56) | KDRFLT3FLT1FLT4ROCK2 | |
| SCHEMBL3384615 | 0.75 | SMN1; SMN2 (0.53) | MAP2K7FLT3MAP4K1ROCK2ROCK1 | |
| SCHEMBL1330072 | 0.74 | KDR (0.75) | KDRMAP2K7FLT3FLT1FLT4 | |
| SCHEMBL3385660 | 0.74 | KDR (0.78) | KDRFLT3FLT1FLT4ROCK2 | |
| SCHEMBL12090187 | 0.73 | MAPK1 (0.50) | FLT3MAP4K1ITK | |
| SCHEMBL13336967 | 0.72 | KDR (0.61) | KDRFLT3MAP4K1FLT1FLT4 | |
| SCHEMBL3387051 | 0.72 | KDR (0.47) | KDRAURKAGSK3BAAK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010064875-A2 | NOVEL INDAZOLE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS PROTEIN KINASE INHIBITORS FOR PROLIFERATIVE DISEASES TREATMENT, AND A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME AS AN ACTIVE INGREDIENT | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2010-06-10 | — | — | WO | claimed |
| WO-2010064875-A2 | NOVEL INDAZOLE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS PROTEIN KINASE INHIBITORS FOR PROLIFERATIVE DISEASES TREATMENT, AND A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME AS AN ACTIVE INGREDIENT | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2010-06-10 | — | — | WO | disclosed |