Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | SCN1A | P35498 | 1/20 | 0.45 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.45 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 3/20 | 0.43 |
| ▸ | HTR1A | P08908 | 2/20 | 0.43 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.43 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.43 |
| ▸ | MPO | P05164 | 3/20 | 0.42 |
| ▸ | HTR1D | P28221 | 2/20 | 0.42 |
| ▸ | BIRC5 | O15392 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 2/20 | 0.40 |
| ▸ | HTR3A | P46098 | 2/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3382239 | 0.84 | SLC6A4 (0.45) | PIM1HTR1APIM3PIM2MPO | |
| SCHEMBL3383870 | 0.75 | HTR1D (0.46) | CYP2D6CYP1A2HTR1AHTR1DBIRC5 | |
| SCHEMBL11233185 | 0.75 | KDM4E (0.65) | CYP2D6CYP1A2SCN1ASCN2ASCN3A | |
| SCHEMBL13496586 | 0.75 | KDM4E (0.41) | CYP2D6CYP1A2SCN1ASCN2ASCN3A | |
| SCHEMBL3857789 | 0.74 | BIRC5 (0.51) | CYP2D6CYP1A2SCN1ASCN2ASCN3A | |
| SCHEMBL4008111 | 0.74 | PRKCI (0.56) | CYP2D6CYP1A2SCN1ASCN2ASCN3A | |
| Hydrochloric Acid SCHEMBL11225332 | 0.74 | MAPT (0.68) | CYP2D6CYP1A2SCN1ASCN2ASCN3A | |
| SCHEMBL3383493 | 0.73 | TUBB4A (0.39) | CYP2D6CYP1A2HTR1AHTR1DHTR2C | |
| SCHEMBL3616464 | 0.73 | BIRC5 (0.54) | CYP2D6CYP1A2SCN1ASCN2ASCN3A | |
| SCHEMBL6807627 | 0.73 | CYP2D6 (0.53) | CYP2D6CYP1A2SCN1ASCN2ASCN3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2149573-A1 | Substituted indole sulfonamide compounds their preparation and use as medicaments | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2010-02-03 | — | — | EP | disclosed |