Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 2/20 | 0.45 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 3/20 | 0.43 |
| ▸ | HTR1D | P28221 | 2/20 | 0.42 |
| ▸ | HTR7 | P34969 | 2/20 | 0.42 |
| ▸ | HTR6 | P50406 | 2/20 | 0.42 |
| ▸ | HTR2A | P28223 | 2/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.42 |
| ▸ | HTR1B | P28222 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | HTR1E | P28566 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3563897 | 0.86 | SLC6A4 (0.57) | SLC6A4GPR84HTR1AHTR1DHTR7 | |
| SCHEMBL3383496 | 0.84 | CYP2D6 (0.45) | HTR1AHTR1DHTR6HTR2CHRH3 | |
| SCHEMBL3383870 | 0.75 | HTR1D (0.46) | HTR1AHTR1DHTR6DRD2DRD3 | |
| SCHEMBL1827429 | 0.75 | SMN1; SMN2 (0.46) | SMN1; SMN2KDM4EALDH1A1TDP1ALK | |
| SCHEMBL3461673 | 0.74 | SMN1; SMN2 (0.46) | SMN1; SMN2KDRPIM3KDM4EALDH1A1 | |
| SCHEMBL12713875 | 0.73 | IDO1 (0.60) | SLC6A4GPR84HTR1AHTR7HTR6 | |
| SCHEMBL31744724 | 0.73 | GPR84 (0.50) | SLC6A4GPR84HTR1AHTR1DHTR2A | |
| SCHEMBL2977755 | 0.73 | KDR (0.53) | DRD2DRD3BIRC5KDRKDM4E | |
| SCHEMBL12990370 | 0.70 | PTGDR2 (0.55) | DRD2DRD3BIRC5KDRKDM4E | |
| SCHEMBL31744744 | 0.70 | SLC6A4 (0.51) | SLC6A4GPR84HTR1DHTR2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2149573-A1 | Substituted indole sulfonamide compounds their preparation and use as medicaments | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2010-02-03 | — | — | EP | disclosed |