Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 4/20 | 0.49 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 15/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 12/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.43 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.43 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3385484 | 0.97 | KDR (0.47) | KDRFGFR3ROCK1ROCK2SMN1; SMN2 | |
| SCHEMBL3384408 | 0.86 | KDR (0.50) | KDRFGFR3 | |
| SCHEMBL3380736 | 0.86 | KDR (0.50) | KDRFGFR3 | |
| SCHEMBL3385883 | 0.84 | KDR (0.50) | KDRFGFR3 | |
| SCHEMBL3385035 | 0.84 | KDR (0.49) | KDRFGFR3 | |
| SCHEMBL3385811 | 0.84 | KDR (0.49) | KDRFGFR3 | |
| SCHEMBL3385534 | 0.81 | KDR (0.50) | KDRFGFR3 | |
| SCHEMBL3385831 | 0.81 | KDR (0.48) | KDRFGFR3ROCK1ROCK2 | |
| SCHEMBL3385490 | 0.80 | FLT3 (0.43) | KDRFGFR3 | |
| SCHEMBL3382607 | 0.78 | FLT3 (0.46) | KDRFGFR3ROCK1ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904494-B1 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS VEGF-R2 INHIBITORS | LILLY CO ELI (US) | 2010-12-01 | — | — | EP | disclosed |