Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR known ✓ | P35968 | 11/20 | 0.46 |
| ▸ | PIK3CA known ✓ | P42336 | 1/20 | 0.40 |
| ▸ | ROCK2 known ✓ | O75116 | 2/20 | 0.39 |
| ▸ | ROCK1 known ✓ | Q13464 | 2/20 | 0.39 |
| ▸ | FLT3 | P36888 | 2/20 | 0.46 |
| ▸ | FGFR3 | P22607 | 8/20 | 0.46 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | ATG4B | Q9Y4P1 | 2/20 | 0.40 |
| ▸ | SGK1 | O00141 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.39 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.39 |
| ▸ | DMPK | Q09013 | 1/20 | 0.39 |
| ▸ | MYLK | Q15746 | 1/20 | 0.39 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3385831 | 0.97 | KDR (0.48) | FLT3KDRFGFR3ATG4BROCK2 | |
| SCHEMBL3386451 | 0.87 | KDR (0.47) | FLT3KDRFGFR3PIK3CAMTOR | |
| SCHEMBL3382515 | 0.85 | CDK2 (0.52) | FLT3KDRFGFR3PIK3CAMTOR | |
| SCHEMBL3380736 | 0.84 | KDR (0.50) | FLT3KDRFGFR3ATG4B | |
| SCHEMBL3385484 | 0.82 | KDR (0.47) | FLT3KDRFGFR3ROCK2ROCK1 | |
| SCHEMBL3382610 | 0.81 | FLT3 (0.43) | FLT3KDRFGFR3PIK3CAMTOR | |
| SCHEMBL3384408 | 0.81 | KDR (0.50) | FLT3KDRFGFR3 | |
| SCHEMBL3385506 | 0.79 | KDR (0.44) | FLT3KDRFGFR3PIK3CAMTOR | |
| SCHEMBL3386064 | 0.79 | FLT3 (0.51) | FLT3KDRFGFR3ATG4B | |
| SCHEMBL3383685 | 0.78 | KDR (0.49) | KDRFGFR3ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904494-B1 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS VEGF-R2 INHIBITORS | LILLY CO ELI (US) | 2010-12-01 | — | — | EP | disclosed |