Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.51 |
| ▸ | FLT3 | P36888 | 10/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.40 |
| ▸ | MTOR | P42345 | 2/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3382949 | 0.81 | FLT3 (0.58) | KDRFLT3 | |
| SCHEMBL17556214 | 0.79 | KDR (0.82) | KDRFLT3 | |
| SCHEMBL3186080 | 0.78 | KDR (0.74) | KDRFLT3PIK3CAMTOR | |
| SCHEMBL3196127 | 0.77 | KDR (0.71) | KDRFLT3PIK3CAMTORGABRG2 | |
| SCHEMBL13724672 | 0.76 | ALDH1A1 (0.50) | PIK3CAMTOR | |
| SCHEMBL3025503 | 0.75 | FLT3 (0.42) | KDRFLT3PIK3CAMTORGABRG2 | |
| SCHEMBL3385513 | 0.75 | FLT3 (0.61) | KDRFLT3 | |
| SCHEMBL3029113 | 0.74 | GABRG2 (0.51) | KDRFLT3GABRG2GABRB3GABRA3 | |
| SCHEMBL3189331 | 0.74 | KDR (0.53) | KDRFLT3 | |
| SCHEMBL3178429 | 0.73 | KDR (0.53) | KDRFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904494-B1 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS VEGF-R2 INHIBITORS | LILLY CO ELI (US) | 2010-12-01 | — | — | EP | disclosed |