Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 19/20 | 0.52 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3386815 | 0.90 | ROCK2 (0.56) | ROCK2 | |
| SCHEMBL3384682 | 0.85 | ROCK2 (0.68) | ROCK2 | |
| SCHEMBL3388663 | 0.83 | ROCK2 (0.51) | ROCK2 | |
| SCHEMBL3355166 | 0.82 | ROCK2 (0.49) | ROCK2 | |
| SCHEMBL3388779 | 0.80 | ROCK2 (0.52) | ROCK2ACVR1 | |
| SCHEMBL13362587 | 0.75 | ROCK2 (0.40) | ROCK2 | |
| SCHEMBL13362859 | 0.74 | ROCK2 (0.40) | ROCK2 | |
| SCHEMBL13362739 | 0.74 | ROCK2 (0.73) | ROCK2 | |
| SCHEMBL3386714 | 0.74 | ROCK2 (0.73) | ROCK2 | |
| SCHEMBL13362854 | 0.74 | ROCK2 (0.73) | ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010056758-A1 | QUINAZOLINE DERIVATIVES AS KINASE INHIBITORS | FENG YANGBO (US) | 2010-05-20 | — | — | WO | disclosed |
| WO-2010056758-A1 | QUINAZOLINE DERIVATIVES AS KINASE INHIBITORS | FENG YANGBO (US) | 2010-05-20 | — | — | WO | disclosed |