Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 18/20 | 0.56 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CLK1 | P49759 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3388663 | 0.94 | ROCK2 (0.51) | ROCK2ROCK1ALDH1A1LMNAALOX15 | |
| SCHEMBL3383989 | 0.90 | ROCK2 (0.52) | ROCK2 | |
| SCHEMBL13362739 | 0.85 | ROCK2 (0.73) | ROCK2 | |
| SCHEMBL13362854 | 0.85 | ROCK2 (0.73) | ROCK2 | |
| SCHEMBL3386714 | 0.85 | ROCK2 (0.73) | ROCK2 | |
| SCHEMBL3388779 | 0.83 | ROCK2 (0.52) | ROCK2ROCK1 | |
| SCHEMBL3356239 | 0.83 | ROCK2 (0.56) | ROCK2ROCK1ALOX15ALOX12 | |
| SCHEMBL3359299 | 0.80 | ROCK2 (0.55) | ROCK2ROCK1ALOX15ALOX12 | |
| SCHEMBL3388227 | 0.79 | ROCK2 (0.67) | ROCK2 | |
| SCHEMBL3356118 | 0.78 | ROCK2 (0.67) | ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010056758-A1 | QUINAZOLINE DERIVATIVES AS KINASE INHIBITORS | FENG YANGBO (US) | 2010-05-20 | — | — | WO | disclosed |