Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 13/20 | 0.56 |
| ▸ | FGFR3 | P22607 | 11/20 | 0.56 |
| ▸ | FLT3 | P36888 | 3/20 | 0.48 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.45 |
| ▸ | MTOR | P42345 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3184870 | 0.91 | KDR (0.61) | KDRFGFR3 | |
| SCHEMBL3384190 | 0.91 | KDR (0.62) | KDRFGFR3 | |
| SCHEMBL17556158 | 0.88 | KDR (0.69) | KDRFGFR3FLT3PIK3CAMTOR | |
| SCHEMBL3382710 | 0.86 | MAPK14 (0.60) | KDRFGFR3 | |
| SCHEMBL3385504 | 0.86 | RAF1 (0.56) | KDRFGFR3FLT3 | |
| SCHEMBL3386414 | 0.86 | RAF1 (0.58) | KDRFGFR3FLT3 | |
| SCHEMBL3382499 | 0.86 | KDR (0.55) | KDRFGFR3FLT3PIK3CAMTOR | |
| SCHEMBL3385889 | 0.85 | RAF1 (0.56) | KDRFGFR3FLT3 | |
| SCHEMBL3385731 | 0.85 | KDR (0.50) | KDRFGFR3FLT3PIK3CAMTOR | |
| SCHEMBL3190830 | 0.84 | KDR (0.66) | KDRFGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904494-B1 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS VEGF-R2 INHIBITORS | LILLY CO ELI (US) | 2010-12-01 | — | — | EP | disclosed |