Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | KDR | P35968 | 8/20 | 0.51 |
| ▸ | FGFR3 | P22607 | 6/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | BLM | P54132 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3386448 | 0.89 | FLT3 (0.54) | RAF1RAB9ANPC1KDRFGFR3 | |
| SCHEMBL3385859 | 0.88 | NPC1 (0.48) | RAF1RAB9ANPC1KDRFGFR3 | |
| SCHEMBL3384408 | 0.88 | KDR (0.50) | RAF1KDRFGFR3FLT3 | |
| SCHEMBL3385521 | 0.86 | ALDH1A1 (0.55) | KDRFGFR3FLT3CYP3A4 | |
| SCHEMBL3384029 | 0.86 | KDR (0.56) | KDRFGFR3FLT3 | |
| SCHEMBL3383417 | 0.84 | FLT3 (0.49) | KDRFGFR3FLT3 | |
| SCHEMBL3384061 | 0.82 | KDR (0.56) | KDRFGFR3 | |
| SCHEMBL3382515 | 0.82 | CDK2 (0.52) | KDRFGFR3FLT3 | |
| SCHEMBL3184870 | 0.82 | KDR (0.61) | RAF1KDRFGFR3 | |
| SCHEMBL3384190 | 0.81 | KDR (0.62) | KDRFGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904494-B1 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS VEGF-R2 INHIBITORS | LILLY CO ELI (US) | 2010-12-01 | — | — | EP | disclosed |