Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 1/20 | 0.56 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.52 |
| ▸ | KDR | P35968 | 5/20 | 0.51 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.51 |
| ▸ | RET | P07949 | 1/20 | 0.51 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.51 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.50 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.47 |
| ▸ | FLT3 | P36888 | 4/20 | 0.44 |
| ▸ | NEK7 | Q8TDX7 | 2/20 | 0.44 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.43 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.43 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3385035 | 0.88 | KDR (0.49) | RAF1MAPK14KDRFGFR3MAPK13 | |
| SCHEMBL3384029 | 0.85 | KDR (0.56) | KDRFGFR3FLT3 | |
| SCHEMBL3386414 | 0.85 | RAF1 (0.58) | RAF1MAPK14KDRRETFGFR3 | |
| SCHEMBL3382710 | 0.83 | MAPK14 (0.60) | RAF1MAPK14KDRNTRK1RET | |
| SCHEMBL3383255 | 0.83 | KDR (0.55) | MAPK14KDRFGFR3MAPK13 | |
| SCHEMBL3385731 | 0.82 | KDR (0.50) | KDRFGFR3FLT3PTK2 | |
| SCHEMBL3382499 | 0.81 | KDR (0.55) | KDRFGFR3FLT3 | |
| SCHEMBL3386477 | 0.81 | KDR (0.47) | MAPK14KDRFGFR3MAPK13FLT3 | |
| SCHEMBL3184870 | 0.81 | KDR (0.61) | RAF1KDRFGFR3 | |
| SCHEMBL3384190 | 0.80 | KDR (0.62) | KDRNTRK1FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904494-B1 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS VEGF-R2 INHIBITORS | LILLY CO ELI (US) | 2010-12-01 | — | — | EP | disclosed |