SCHEMBL3384558

SCHEMBL3384558

Cc1sc2ncnc(C(N)c3ccccn3)c2c1-c1ccccc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FGFR1 P11362 1/20 0.46
KDR P35968 4/20 0.45
SMN1; SMN2 Q16637 3/20 0.45
HTT P42858 2/20 0.45
ATM Q13315 1/20 0.45
MAPK1 P28482 1/20 0.43
CSNK2A2 P19784 3/20 0.43
CSNK2B P67870 3/20 0.43
CSNK2A1 P68400 3/20 0.43
KIT P10721 2/20 0.43
TEK Q02763 2/20 0.43
MEN1 O00255 3/20 0.43
KMT2A Q03164 3/20 0.43
NOD2 Q9HC29 1/20 0.41
ALDH1A1 P00352 4/20 0.40
KDM4E B2RXH2 2/20 0.40
HPGD P15428 1/20 0.40
MAPT P10636 1/20 0.40
LIMK1 P53667 1/20 0.40
LMNA P02545 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3382775 0.86 EGFR (0.36) FGFR1KDRSMN1; SMN2HTTATM
SCHEMBL2369059 0.76 FGFR1 (0.56) FGFR1KDRSMN1; SMN2HTTMAPK1
SCHEMBL2903706 0.75 SMN1; SMN2 (0.47) FGFR1KDRSMN1; SMN2HTTATM
SCHEMBL14013967 0.74 KDR (0.78) FGFR1KDRKITTEKLIMK1
SCHEMBL2368686 0.71 EGFR (0.37) FGFR1KDRSMN1; SMN2HTTMAPK1
SCHEMBL2368680 0.71 FGFR1 (0.55) FGFR1KDRSMN1; SMN2HTTMAPK1
SCHEMBL6665665 0.71 FGFR1 (0.62) FGFR1KDRSMN1; SMN2HTTMAPK1
SCHEMBL3381240 0.70 LMNA (0.48) FGFR1KDRSMN1; SMN2HTTMAPK1
SCHEMBL2369054 0.70 MAP4K4 (0.43) FGFR1KDRSMN1; SMN2HTTMAPK1
SCHEMBL3384562 0.68 TNF (0.61) FGFR1SMN1; SMN2HTTMAPK1CSNK2A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1641803-B3 THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS XENTION LTD (GB) 2010-12-08 EP disclosed
EP-1641803-B1 THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS XENTION LTD (GB) 2009-03-18 EP disclosed
EP-1641803-A1 THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS Xention Discovery Limited (GB) 2006-04-05 EP disclosed
WO-2004111057-A1 THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS XENTION DISCOVERY LIMITED (GB) 2004-12-23 WO disclosed