Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 16/20 | 0.59 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.59 |
| ▸ | MARK3 | P27448 | 2/20 | 0.47 |
| ▸ | MARK4 | Q96L34 | 2/20 | 0.47 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.47 |
| ▸ | ULK1 | O75385 | 4/20 | 0.46 |
| ▸ | ULK2 | Q8IYT8 | 4/20 | 0.46 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.45 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.45 |
| ▸ | SIK1 | P57059 | 1/20 | 0.45 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.45 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.45 |
| ▸ | MELK | Q14680 | 1/20 | 0.45 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.45 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.45 |
| ▸ | NUAK2 | Q9H093 | 1/20 | 0.45 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.45 |
| ▸ | MARK1 | Q9P0L2 | 1/20 | 0.45 |
| ▸ | SIK3 | Q9Y2K2 | 1/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3389058 | 0.86 | TBK1 (0.61) | TBK1PDPK1MARK3MARK4STK17A | |
| SCHEMBL3388473 | 0.85 | TBK1 (0.64) | TBK1PDPK1MARK3MARK4STK17A | |
| SCHEMBL13431861 | 0.84 | TBK1 (0.63) | TBK1PDPK1MARK3MARK4STK17A | |
| SCHEMBL3387821 | 0.80 | TBK1 (0.71) | TBK1PDPK1MARK3MARK4STK17A | |
| SCHEMBL13431863 | 0.80 | TBK1 (0.62) | TBK1PDPK1MARK3MARK4STK17A | |
| Hydrochloric Acid SCHEMBL3384518 | 0.79 | TBK1 (0.70) | TBK1PDPK1MARK3MARK4STK17A | |
| SCHEMBL3383882 | 0.79 | TBK1 (0.69) | TBK1PDPK1MARK3MARK4STK17A | |
| SCHEMBL4055333 | 0.78 | TBK1 (0.59) | TBK1PDPK1MARK3MARK4STK17A | |
| SCHEMBL3386145 | 0.78 | TBK1 (0.39) | TBK1MARK3ULK1ULK2IKBKE | |
| SCHEMBL13460122 | 0.78 | TBK1 (0.71) | TBK1PDPK1MARK3MARK4STK17A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100056524-A1 | Compound | MEDICAL RESEARCH COUNCIL TECHNOLOGY (GB) | 2010-03-04 | — | — | US | disclosed |
| US-20100056524-A1 | Compound | MEDICAL RESEARCH COUNCIL TECHNOLOGY (GB) | 2010-03-04 | — | — | US | disclosed |
| US-20100056524-A1 | Compound | MEDICAL RESEARCH COUNCIL TECHNOLOGY (GB) | 2010-03-04 | — | — | US | disclosed |
| WO-2009122180-A1 | PYRIMIDINE DERIVATIVES CAPABLE OF INHIBITING ONE OR MORE KINASES | MEDICAL RESEARCH COUNCIL (GB) | 2009-10-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100056524-A1 | Compound | NR3C2, NR3C1, NR2E3 | TBK1 2898/4885PDPK1 2468/4885MARK3 1239/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.