Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAA1 | Q13131 | 4/20 | 0.53 |
| ▸ | PRKAG1 | P54619 | 3/20 | 0.53 |
| ▸ | PRKAB1 | Q9Y478 | 3/20 | 0.53 |
| ▸ | CDK2 | P24941 | 2/20 | 0.48 |
| ▸ | FLT3 | P36888 | 2/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.48 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | MARK3 | P27448 | 1/20 | 0.46 |
| ▸ | CLK2 | P49760 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.46 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.46 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.46 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.46 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.46 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3385482 | 0.89 | NPC1 (0.49) | PRKAA1PRKAG1PRKAB1CDK2FLT3 | |
| SCHEMBL3382225 | 0.79 | PRKAG1 (0.56) | PRKAA1PRKAG1PRKAB1CDK2FLT3 | |
| SCHEMBL3380526 | 0.76 | PRKAG1 (0.48) | PRKAA1PRKAG1PRKAB1CDK2FLT3 | |
| SCHEMBL3386872 | 0.76 | KDM4E (0.56) | KDM4ELMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL3383247 | 0.75 | HPGD (0.53) | PRKAA1PRKAG1PRKAB1CDK2FLT3 | |
| SCHEMBL176882 | 0.75 | PRKAG1 (0.66) | PRKAA1PRKAG1PRKAB1CDK2FLT3 | |
| SCHEMBL3380466 | 0.72 | PAK1 (0.47) | PRKAA1PRKAG1PRKAB1ROCK1CLK2 | |
| SCHEMBL3386831 | 0.71 | NPC1 (0.54) | PRKAA1PRKAG1PRKAB1FLT3NPC1 | |
| SCHEMBL4493778 | 0.70 | HDAC6 (0.66) | HDAC6FGFR4 | |
| SCHEMBL3386582 | 0.70 | FLT3 (0.53) | PRKAA1PRKAG1PRKAB1CDK2FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010064875-A2 | NOVEL INDAZOLE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS PROTEIN KINASE INHIBITORS FOR PROLIFERATIVE DISEASES TREATMENT, AND A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME AS AN ACTIVE INGREDIENT | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2010-06-10 | — | — | WO | claimed |
| WO-2010064875-A2 | NOVEL INDAZOLE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS PROTEIN KINASE INHIBITORS FOR PROLIFERATIVE DISEASES TREATMENT, AND A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME AS AN ACTIVE INGREDIENT | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2010-06-10 | — | — | WO | disclosed |