Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.35 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.32 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.32 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.32 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL251389 | 0.90 | ABCC9 (0.36) | ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL252703 | 0.81 | MEN1 (0.37) | ABCC9ABCC8KCNJ11KCNJ8L3MBTL1 | |
| SCHEMBL2153420 | 0.68 | BACE1 (0.41) | ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL251767 | 0.67 | ALDH1A1 (0.40) | — | |
| SCHEMBL12525453 | 0.64 | BACE1 (0.34) | L3MBTL1 | |
| SCHEMBL12524922 | 0.62 | BACE1 (0.34) | L3MBTL1 | |
| SCHEMBL251000 | 0.61 | BACE1 (0.50) | ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL247369 | 0.61 | BACE1 (0.36) | ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL9959296 | 0.60 | BACE1 (0.38) | — | |
| SCHEMBL16311227 | 0.60 | BACE1 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012000933-A1 | 3-AMINO-5,6-DIHYDRO-1H-PYRAZIN-2-ONE DERIVATIVES USEFUL FOR THE TREATEMENT OF ALZHEIMER'S DISEASE AND OTHER FORMS OF DEMENTIA | JANSSEN PHARMACEUTICA NV (BE) | 2012-01-05 | — | — | WO | disclosed |