Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 6/20 | 0.43 |
| ▸ | PTGFR | P43088 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 7/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.33 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.33 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3386091 | 0.91 | HSD11B1 (0.46) | HSD11B1PTGFRALDH1A1LMNAGLA | |
| SCHEMBL3386093 | 0.91 | HSD11B1 (0.46) | HSD11B1PTGFRALDH1A1LMNAGLA | |
| SCHEMBL3386882 | 0.88 | HSD11B1 (0.44) | HSD11B1PTGFRALDH1A1LMNAGLA | |
| SCHEMBL3386891 | 0.88 | HSD11B1 (0.44) | HSD11B1PTGFRALDH1A1LMNAGLA | |
| SCHEMBL3384969 | 0.87 | HSD11B1 (0.44) | HSD11B1PTGFRALDH1A1LMNAGLA | |
| SCHEMBL3385895 | 0.87 | HSD11B1 (0.44) | HSD11B1PTGFRALDH1A1LMNAGLA | |
| SCHEMBL3381695 | 0.85 | PTGFR (0.49) | HSD11B1PTGFRALDH1A1DRD2S1PR2 | |
| SCHEMBL3382814 | 0.85 | PTGFR (0.49) | HSD11B1PTGFRALDH1A1DRD2S1PR2 | |
| SCHEMBL3383876 | 0.85 | PTGFR (0.42) | HSD11B1PTGFRALDH1A1DRD2S1PR2 | |
| SCHEMBL3380122 | 0.85 | PTGFR (0.49) | HSD11B1PTGFRALDH1A1DRD2S1PR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487442-B1 | THIAZOLIDINE CARBOXAMIDE DERIVATIVES AS MODULATORS OF THE PROSTAGLANDIN F RECEPTOR | MERCK SERONO SA (CH) | 2010-12-01 | — | — | EP | claimed |