Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.46 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.46 |
| ▸ | FLT3 | P36888 | 10/20 | 0.46 |
| ▸ | RET | P07949 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3381118 | 0.89 | NPC1 (0.54) | NPC1RAB9AMAPK14MAPK13FLT3 | |
| SCHEMBL3381854 | 0.89 | NPC1 (0.49) | NPC1RAB9AMAPK14MAPK13FLT3 | |
| SCHEMBL3383303 | 0.89 | NPC1 (0.52) | NPC1RAB9AMAPK14MAPK13FLT3 | |
| SCHEMBL3385839 | 0.88 | NPC1 (0.51) | NPC1RAB9AMAPK14MAPK13FLT3 | |
| SCHEMBL3383068 | 0.87 | NPC1 (0.50) | NPC1RAB9AMAPK14MAPK13FLT3 | |
| SCHEMBL3198885 | 0.85 | NPC1 (0.53) | NPC1RAB9AMAPK14MAPK13FLT3 | |
| SCHEMBL3381837 | 0.85 | NPC1 (0.48) | NPC1RAB9AMAPK14MAPK13FLT3 | |
| SCHEMBL13002517 | 0.85 | FLT3 (0.48) | NPC1RAB9AMAPK14MAPK13FLT3 | |
| Hydrochloric Acid SCHEMBL3189282 | 0.84 | FLT3 (0.47) | NPC1RAB9AMAPK14MAPK13FLT3 | |
| Hydrochloric Acid SCHEMBL3185922 | 0.84 | MAPK14 (0.48) | NPC1RAB9AMAPK14MAPK13FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904494-B1 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS VEGF-R2 INHIBITORS | LILLY CO ELI (US) | 2010-12-01 | — | — | EP | disclosed |