Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | BTK | Q06187 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL338526 | 1.00 | MEN1 (0.37) | MEN1MAPK1KMT2APSMB5GAA | |
| SCHEMBL338528 | 1.00 | MEN1 (0.37) | MEN1MAPK1KMT2APSMB5GAA | |
| SCHEMBL3375121 | 0.77 | MEN1 (0.38) | MEN1MAPK1KMT2APSMB5GAA | |
| SCHEMBL3398243 | 0.77 | MEN1 (0.38) | MEN1MAPK1KMT2APSMB5GAA | |
| SCHEMBL3389134 | 0.77 | MEN1 (0.38) | MEN1MAPK1KMT2APSMB5GAA | |
| SCHEMBL30124181 | 0.64 | MEN1 (0.37) | MEN1MAPK1KMT2AGAABTK | |
| SCHEMBL3375329 | 0.63 | MEN1 (0.35) | MEN1MAPK1KMT2APSMB5BTK | |
| Ammonia Solution, Strong SCHEMBL28412752 | 0.63 | MEN1 (0.47) | MEN1MAPK1KMT2AGAABTK | |
| SCHEMBL24459163 | 0.62 | MEN1 (0.44) | MEN1MAPK1KMT2AGAABTK | |
| SCHEMBL31333338 | 0.61 | BTK (0.55) | KMT2AGAABTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8563559-B2 | Pinane-substituted pyrimidinediamine derivatives useful as Axl inhibitors | RIGEL PHARMACEUTICALS, INC. (US) | 2013-10-22 | — | — | US | disclosed |
| US-20120088768-A1 | PINANE-SUBSTITUTED PYRIMIDINEDIAMINE DERIVATIVES USEFUL AS AXL INHIBITORS | RIGEL PHARMACEUTICALS, INC. (US) | 2012-04-12 | — | — | US | disclosed |
| US-8097630-B2 | Pinane-substituted pyrimidinediamine derivatives derivatives and pharmaceutical compositions containing the dthe activity of the receptor protein tyrosine kinase Axl. Methods of using erivatives are disclosed as being useful in inhibiting activity of enzyme | RIGEL PHARMACEUTICALS, INC. (US) | 2012-01-17 | — | — | US | disclosed |
| US-20080153815-A1 | PINANE-SUBSTITUTED PYRIMIDINEDIAMINE DERIVATIVES USEFUL AS AXL INHIBITORS | RIGEL PHARMACEUTICALS, INC. (US) | 2008-06-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120088768-A1 | PINANE-SUBSTITUTED PYRIMIDINEDIAMINE DERIVATIVES USEFUL AS AXL INHIBITORS | AXL, TYRO3, ERBB2 | MEN1 4368/4885MAPK1 296/4885KMT2A 2954/4885 |
| US-20080153815-A1 | PINANE-SUBSTITUTED PYRIMIDINEDIAMINE DERIVATIVES USEFUL AS AXL INHIBITORS | AXL, TYRO3, MERTK | MEN1 4367/4885MAPK1 333/4885KMT2A 3115/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.