Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.45 |
| ▸ | FGFR3 | P22607 | 6/20 | 0.45 |
| ▸ | FLT3 | P36888 | 6/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3382113 | 0.91 | KDR (0.50) | KDRFGFR3FLT3NAMPTEPHX2 | |
| SCHEMBL3386534 | 0.90 | FLT3 (0.53) | KDRFGFR3FLT3NAMPT | |
| SCHEMBL3385517 | 0.89 | EPHX2 (0.55) | KDRFGFR3NAMPTEPHX2PTGS2 | |
| SCHEMBL3381849 | 0.88 | RORC (0.48) | KDRFGFR3FLT3NAMPTEPHX2 | |
| SCHEMBL3380798 | 0.88 | FLT3 (0.49) | KDRFGFR3FLT3NAMPT | |
| SCHEMBL3385549 | 0.88 | KDR (0.47) | KDRFGFR3FLT3NAMPT | |
| SCHEMBL3385176 | 0.87 | NAMPT (0.47) | KDRFGFR3FLT3NAMPT | |
| SCHEMBL3386178 | 0.87 | NAMPT (0.47) | KDRFGFR3FLT3NAMPT | |
| SCHEMBL3380684 | 0.86 | EPHX2 (0.53) | KDRFGFR3FLT3NAMPTEPHX2 | |
| SCHEMBL3381951 | 0.85 | FLT3 (0.58) | KDRFGFR3FLT3NAMPTEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904494-B1 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS VEGF-R2 INHIBITORS | LILLY CO ELI (US) | 2010-12-01 | — | — | EP | disclosed |