Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 4/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.52 |
| ▸ | NAMPT | P43490 | 7/20 | 0.50 |
| ▸ | KDR | P35968 | 3/20 | 0.49 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3382113 | 0.94 | KDR (0.50) | FLT3NAMPTKDRFGFR3 | |
| SCHEMBL3385042 | 0.91 | KDR (0.55) | FLT3NAMPTKDRFGFR3SMN1; SMN2 | |
| SCHEMBL3381849 | 0.91 | RORC (0.48) | FLT3NAMPTKDRFGFR3 | |
| SCHEMBL3385549 | 0.91 | KDR (0.47) | FLT3NAMPTKDRFGFR3 | |
| SCHEMBL3380798 | 0.91 | FLT3 (0.49) | FLT3NAMPTKDRFGFR3 | |
| SCHEMBL3385517 | 0.90 | EPHX2 (0.55) | NAMPTKDRFGFR3 | |
| SCHEMBL3385494 | 0.90 | KDR (0.45) | FLT3NAMPTKDRFGFR3 | |
| SCHEMBL3386178 | 0.90 | NAMPT (0.47) | FLT3NAMPTKDRFGFR3 | |
| SCHEMBL3385176 | 0.88 | NAMPT (0.47) | FLT3NAMPTKDRFGFR3 | |
| SCHEMBL3381951 | 0.88 | FLT3 (0.58) | FLT3NAMPTKDRFGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904494-B1 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS VEGF-R2 INHIBITORS | LILLY CO ELI (US) | 2010-12-01 | — | — | EP | disclosed |