Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.30 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3200515 | 0.84 | SMN1; SMN2 (0.39) | NOS1SMN1; SMN2ALDH1A1HPGDALOX15 | |
| SCHEMBL9126942 | 0.81 | SMN1; SMN2 (0.35) | SMN1; SMN2 | |
| SCHEMBL12524984 | 0.72 | NOS1 (0.30) | NOS1 | |
| SCHEMBL5875592 | 0.68 | OPRL1 (0.56) | ALDH1A1 | |
| SCHEMBL17055342 | 0.66 | OGA (0.40) | SMN1; SMN2CYP11B2CYP11B1 | |
| SCHEMBL3634429 | 0.66 | CYP11B2 (0.30) | CYP11B2 | |
| SCHEMBL3634806 | 0.65 | SYK (0.38) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL24784411 | 0.64 | HCAR2 (0.39) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL9085983 | 0.64 | HTT (0.36) | GAAHPGD | |
| SCHEMBL3632095 | 0.63 | SYK (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904494-B1 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS VEGF-R2 INHIBITORS | LILLY CO ELI (US) | 2010-12-01 | — | — | EP | disclosed |