Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR known ✓ | P35968 | 2/20 | 0.51 |
| ▸ | PIK3CA known ✓ | P42336 | 1/20 | 0.48 |
| ▸ | PDGFRB known ✓ | P09619 | 1/20 | 0.47 |
| ▸ | KIT known ✓ | P10721 | 1/20 | 0.47 |
| ▸ | FLT3 | P36888 | 9/20 | 0.54 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.51 |
| ▸ | MTOR | P42345 | 1/20 | 0.48 |
| ▸ | RAF1 | P04049 | 5/20 | 0.48 |
| ▸ | CSF1R | P07333 | 1/20 | 0.47 |
| ▸ | RET | P07949 | 1/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.46 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3381854 | 0.89 | NPC1 (0.49) | FLT3KDRFGFR3PIK3CAMTOR | |
| SCHEMBL3386414 | 0.88 | RAF1 (0.58) | FLT3KDRFGFR3RAF1CSF1R | |
| SCHEMBL3383492 | 0.87 | FLT3 (0.50) | FLT3KDRRAF1CSF1RRET | |
| SCHEMBL3380805 | 0.84 | FLT3 (0.57) | FLT3KDRFGFR3RAF1CSF1R | |
| SCHEMBL3385510 | 0.83 | MAPK14 (0.48) | FLT3KDRRAF1CSF1RRET | |
| SCHEMBL3385688 | 0.83 | PIK3CA (0.46) | FLT3KDRFGFR3PIK3CAMTOR | |
| SCHEMBL3197428 | 0.81 | FLT3 (0.47) | FLT3KDRFGFR3RAF1CSF1R | |
| SCHEMBL3385873 | 0.80 | FLT3 (0.49) | FLT3KDRRAF1CSF1RRET | |
| SCHEMBL3382975 | 0.80 | FLT3 (0.49) | FLT3KDRRAF1CSF1RMEN1 | |
| SCHEMBL3189927 | 0.79 | KDR (0.57) | FLT3KDRFGFR3RAF1CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904494-B1 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS VEGF-R2 INHIBITORS | LILLY CO ELI (US) | 2010-12-01 | — | — | EP | disclosed |