Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 7/20 | 0.48 |
| ▸ | KDR | P35968 | 4/20 | 0.45 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.42 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.42 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.42 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3176929 | 0.92 | FLT3 (0.45) | FLT3KDRFGFR3MAPK14MAPK11 | |
| SCHEMBL3385883 | 0.90 | KDR (0.50) | KDRFGFR3MAPK14MAPK11MAPK13 | |
| SCHEMBL3385711 | 0.89 | MAPK14 (0.51) | FLT3MAPK14MAPK11MAPK13MAPK12 | |
| SCHEMBL3194454 | 0.89 | FLT3 (0.43) | FLT3KDRFGFR3MAPK14MAPK11 | |
| SCHEMBL3383385 | 0.88 | MAPK14 (0.51) | FLT3KDRRETMAPK14MAPK11 | |
| SCHEMBL3381768 | 0.88 | FLT3 (0.42) | FLT3KDRFGFR3MAPK14MAPK11 | |
| SCHEMBL3184816 | 0.87 | FLT3 (0.41) | FLT3KDRFGFR3MAPK14MAPK11 | |
| SCHEMBL3194250 | 0.87 | FLT3 (0.41) | FLT3KDRFGFR3MAPK14MAPK11 | |
| SCHEMBL3383188 | 0.87 | FLT3 (0.48) | FLT3KDRFGFR3RETMAPK14 | |
| SCHEMBL3381138 | 0.86 | KDR (0.42) | KDRFGFR3RETMAPK14MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904494-B1 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS VEGF-R2 INHIBITORS | LILLY CO ELI (US) | 2010-12-01 | — | — | EP | disclosed |