Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 14/20 | 0.47 |
| ▸ | FGFR3 | P22607 | 12/20 | 0.47 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | PPID | Q08752 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3385035 | 0.93 | KDR (0.49) | KDRFGFR3MAPK13MAPK14FLT3 | |
| SCHEMBL3381305 | 0.91 | KDR (0.46) | KDRFGFR3MAPK13MAPK14FLT3 | |
| SCHEMBL3383467 | 0.91 | FLT3 (0.44) | KDRFGFR3FLT3 | |
| SCHEMBL3383255 | 0.84 | KDR (0.55) | KDRFGFR3MAPK13MAPK14 | |
| SCHEMBL3383349 | 0.83 | FLT3 (0.47) | KDRFGFR3FLT3 | |
| SCHEMBL3385534 | 0.82 | KDR (0.50) | KDRFGFR3MAPK13MAPK14FLT3 | |
| SCHEMBL3386223 | 0.82 | FLT3 (0.43) | KDRFGFR3FLT3 | |
| SCHEMBL3385889 | 0.81 | RAF1 (0.56) | KDRFGFR3MAPK13MAPK14FLT3 | |
| SCHEMBL3385590 | 0.81 | MAPK14 (0.40) | KDRFGFR3MAPK13MAPK14FLT3 | |
| SCHEMBL3385883 | 0.79 | KDR (0.50) | KDRFGFR3MAPK13MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904494-B1 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS VEGF-R2 INHIBITORS | LILLY CO ELI (US) | 2010-12-01 | — | — | EP | disclosed |