Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 14/20 | 0.47 |
| ▸ | FGFR3 | P22607 | 13/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3383147 | 0.92 | FGFR3 (0.40) | KDRFGFR3 | |
| SCHEMBL3385736 | 0.90 | KDR (0.50) | KDRFGFR3FLT3 | |
| SCHEMBL3385492 | 0.88 | FGFR3 (0.50) | KDRFGFR3 | |
| SCHEMBL3384220 | 0.86 | KDR (0.47) | KDRFGFR3FLT3PIK3CAMTOR | |
| SCHEMBL3380938 | 0.85 | KDR (0.46) | KDRFGFR3FLT3GABRA1GABRG2 | |
| SCHEMBL3383417 | 0.84 | FLT3 (0.49) | KDRFGFR3FLT3PIK3CAMTOR | |
| SCHEMBL3380736 | 0.83 | KDR (0.50) | KDRFGFR3FLT3 | |
| SCHEMBL3383222 | 0.83 | FGFR3 (0.42) | KDRFGFR3 | |
| SCHEMBL3381118 | 0.82 | NPC1 (0.54) | KDRFGFR3FLT3 | |
| SCHEMBL3385380 | 0.81 | KDR (0.47) | KDRFGFR3FLT3PIK3CAMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904494-B1 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS VEGF-R2 INHIBITORS | LILLY CO ELI (US) | 2010-12-01 | — | — | EP | disclosed |