Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.47 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.46 |
| ▸ | WNT3A | P56704 | 8/20 | 0.45 |
| ▸ | FLT3 | P36888 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.40 |
| ▸ | CDK2 | P24941 | 2/20 | 0.40 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | CDK4 | P11802 | 1/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.40 |
| ▸ | CCND1 | P24385 | 1/20 | 0.40 |
| ▸ | CCND2 | P30279 | 1/20 | 0.40 |
| ▸ | CCND3 | P30281 | 1/20 | 0.40 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13483161 | 0.89 | WNT3A (0.49) | KDRFGFR3WNT3AFLT3CYP3A4 | |
| SCHEMBL3380736 | 0.88 | KDR (0.50) | KDRFGFR3FLT3 | |
| SCHEMBL3385521 | 0.88 | ALDH1A1 (0.55) | KDRFGFR3WNT3AFLT3CYP3A4 | |
| SCHEMBL3382431 | 0.88 | KDR (0.44) | KDRFGFR3FLT3PIK3CAMTOR | |
| SCHEMBL3380938 | 0.88 | KDR (0.46) | KDRFGFR3FLT3 | |
| SCHEMBL3386221 | 0.87 | WNT3A (0.43) | KDRFGFR3WNT3AFLT3CCNE2 | |
| SCHEMBL3383417 | 0.83 | FLT3 (0.49) | KDRFGFR3FLT3PIK3CAMTOR | |
| SCHEMBL3196212 | 0.83 | KDR (0.46) | KDRFGFR3FLT3 | |
| SCHEMBL3385352 | 0.82 | WNT3A (0.49) | KDRFGFR3WNT3A | |
| SCHEMBL3385668 | 0.81 | RET (0.47) | KDRFGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904494-B1 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS VEGF-R2 INHIBITORS | LILLY CO ELI (US) | 2010-12-01 | — | — | EP | disclosed |