SCHEMBL3383147

SCHEMBL3383147

Cc1cc(-c2ccn3c(-c4ccc(NC(=O)Nc5ncc(C(C)(C)C)s5)c(F)c4)cnc3c2)ccn1

nearest known ligand 0.40

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
FGFR3 P22607 19/20 0.40
KDR P35968 17/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3385952 0.92 KDR (0.47) FGFR3KDR
SCHEMBL3383222 0.91 FGFR3 (0.42) FGFR3KDR
SCHEMBL3385796 0.88 PSEN1 (0.44) FGFR3KDR
SCHEMBL3385492 0.87 FGFR3 (0.50) FGFR3KDR
SCHEMBL3383023 0.86 WNT3A (0.43) FGFR3KDR
SCHEMBL3382705 0.83 FGFR3 (0.43) FGFR3KDR
SCHEMBL3385736 0.82 KDR (0.50) FGFR3KDR
SCHEMBL3380739 0.81 WNT3A (0.43) FGFR3KDR
SCHEMBL3385155 0.80 NPC1 (0.49)
SCHEMBL3384220 0.78 KDR (0.47) FGFR3KDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1904494-B1 IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS VEGF-R2 INHIBITORS LILLY CO ELI (US) 2010-12-01 EP disclosed