Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.50 |
| ▸ | HPGD | P15428 | 4/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3386420 | 0.89 | ALDH1A1 (0.45) | ALDH1A1SMN1; SMN2HPGDL3MBTL1NPC1 | |
| SCHEMBL2369058 | 0.81 | ALDH1A1 (0.44) | ALDH1A1SMN1; SMN2HPGDL3MBTL1NPC1 | |
| SCHEMBL2369032 | 0.80 | ALDH1A1 (0.46) | ALDH1A1SMN1; SMN2HPGDL3MBTL1NPC1 | |
| SCHEMBL3384957 | 0.79 | ALDH1A1 (0.44) | ALDH1A1SMN1; SMN2HPGDL3MBTL1NPC1 | |
| SCHEMBL3387832 | 0.79 | ALDH1A1 (0.45) | ALDH1A1SMN1; SMN2HPGDL3MBTL1TRPM8 | |
| SCHEMBL2369050 | 0.78 | ALDH1A1 (0.74) | ALDH1A1SMN1; SMN2HPGDL3MBTL1NPC1 | |
| SCHEMBL2369505 | 0.75 | ALDH1A1 (0.64) | ALDH1A1SMN1; SMN2HPGDL3MBTL1NPC1 | |
| SCHEMBL2369234 | 0.72 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2HPGDL3MBTL1POLB | |
| SCHEMBL8203415 | 0.71 | ALDH1A1 (0.66) | ALDH1A1SMN1; SMN2HPGDNPC1POLB | |
| SCHEMBL6034989 | 0.71 | TGM2 (0.73) | ALDH1A1SMN1; SMN2HPGDL3MBTL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1641803-B3 | THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS | XENTION LTD (GB) | 2010-12-08 | — | — | EP | disclosed |
| EP-1641803-B1 | THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS | XENTION LTD (GB) | 2009-03-18 | — | — | EP | disclosed |
| EP-1641803-A1 | THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS | Xention Discovery Limited (GB) | 2006-04-05 | — | — | EP | disclosed |
| WO-2004111057-A1 | THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS | XENTION DISCOVERY LIMITED (GB) | 2004-12-23 | — | — | WO | disclosed |