Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.50 |
| ▸ | CNR1 | P21554 | 3/20 | 0.45 |
| ▸ | CNR2 | P34972 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 2/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16537813 | 0.88 | ROCK1 (0.48) | EGFRCNR1CNR2KMT2AMEN1 | |
| SCHEMBL1257268 | 0.84 | FLT3 (0.54) | EGFRRAB9AHPGDFLT3KDM4E | |
| SCHEMBL31663638 | 0.80 | KIT (0.53) | EGFRCNR1CNR2FLT3RET | |
| SCHEMBL16536471 | 0.80 | KIT (0.53) | EGFRCNR1CNR2FLT3RET | |
| SCHEMBL3380690 | 0.78 | RIOK2 (0.46) | ROCK1HIF1A | |
| SCHEMBL1258009 | 0.76 | MAPK14 (0.65) | KMT2AMEN1RAB9AFLT3MAPK14 | |
| SCHEMBL25249865 | 0.75 | BTK (0.47) | MAPTHPGDSMN1; SMN2HIF1A | |
| SCHEMBL1256308 | 0.75 | GAPDH (0.44) | EGFRHPGDFLT3KDM4ERET | |
| SCHEMBL27462607 | 0.74 | BTK (0.41) | MAPTKMT2AKDM4E | |
| SCHEMBL5263766 | 0.74 | ROCK1 (0.46) | ROCK1HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904494-B1 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS VEGF-R2 INHIBITORS | LILLY CO ELI (US) | 2010-12-01 | — | — | EP | disclosed |