Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 8/20 | 0.43 |
| ▸ | KDR | P35968 | 10/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 4/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | CLK1 | P49759 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3382610 | 0.88 | FLT3 (0.43) | FLT3KDRFGFR3PIK3CAMTOR | |
| SCHEMBL3385641 | 0.84 | FLT3 (0.45) | FLT3KDRFGFR3PIK3CAMTOR | |
| SCHEMBL3385490 | 0.83 | FLT3 (0.43) | FLT3KDRFGFR3PIK3CAMTOR | |
| SCHEMBL3386451 | 0.81 | KDR (0.47) | FLT3KDRFGFR3PIK3CAMTOR | |
| SCHEMBL3383424 | 0.77 | FLT3 (0.45) | FLT3KDRFGFR3PIK3CAMTOR | |
| SCHEMBL3384517 | 0.72 | KDR (0.51) | FLT3KDRFGFR3 | |
| SCHEMBL3384060 | 0.71 | KDR (0.52) | FLT3KDRFGFR3PIK3CAMTOR | |
| SCHEMBL3382607 | 0.70 | FLT3 (0.46) | FLT3KDRFGFR3PIK3CAMTOR | |
| SCHEMBL3385484 | 0.68 | KDR (0.47) | FLT3KDRFGFR3 | |
| SCHEMBL3384408 | 0.68 | KDR (0.50) | FLT3KDRFGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904494-B1 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS VEGF-R2 INHIBITORS | LILLY CO ELI (US) | 2010-12-01 | — | — | EP | disclosed |