Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 11/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 11/20 | 0.52 |
| ▸ | SLC6A3 | Q01959 | 10/20 | 0.52 |
| ▸ | HTR1A | P08908 | 6/20 | 0.52 |
| ▸ | OPRL1 | P41146 | 4/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 3/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4883036 | 0.98 | SLC6A4 (0.51) | SLC6A2SLC6A4SLC6A3HTR1AOPRL1 | |
| SCHEMBL1824590 | 0.90 | CHRNB2 (0.49) | SLC6A2SLC6A4SLC6A3HTR1AOPRL1 | |
| SCHEMBL4974123 | 0.88 | SLC6A2 (0.52) | SLC6A2SLC6A4SLC6A3HTR1AOPRL1 | |
| Trifluoroacetic Acid SCHEMBL5671633 | 0.87 | OPRL1 (0.49) | SLC6A2SLC6A4SLC6A3HTR1AOPRL1 | |
| SCHEMBL17514569 | 0.87 | OPRL1 (0.55) | SLC6A4OPRL1 | |
| SCHEMBL17229876 | 0.86 | SLC6A2 (0.59) | SLC6A2SLC6A4SLC6A3HTR1AOPRL1 | |
| Hydrochloric Acid SCHEMBL29915700 | 0.84 | SLC6A2 (0.58) | SLC6A2SLC6A4SLC6A3HTR1AOPRL1 | |
| Hydrochloric Acid SCHEMBL17223035 | 0.84 | SLC6A2 (0.58) | SLC6A2SLC6A4SLC6A3HTR1AOPRL1 | |
| SCHEMBL4689150 | 0.83 | OPRL1 (0.49) | SLC6A4OPRL1 | |
| SCHEMBL20315440 | 0.83 | OPRL1 (0.49) | SLC6A4OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963268-B1 | DISUBSTITUTED PHENYLPIPERIDINES AS MODULATORS OF CORTICAL CATECHOLAMINERGIC NEUROTRANSMISSION | NSAB AF NEUROSEARCH SWEDEN AB (DK) | 2010-12-01 | — | — | EP | claimed |
| US-20080269286-A1 | Disubstituted Phenylpiperidines as Modulators of Cortical Catecholaminergic Neurotransmission | NSAB, FILIAL AF NEUROSEARCH SWEDEN AB, SVERIGE (DK) | 2008-10-30 | — | — | US | claimed |
| EP-1963268-B1 | DISUBSTITUTED PHENYLPIPERIDINES AS MODULATORS OF CORTICAL CATECHOLAMINERGIC NEUROTRANSMISSION | NSAB AF NEUROSEARCH SWEDEN AB (DK) | 2010-12-01 | — | — | EP | disclosed |
| US-20080269286-A1 | Disubstituted Phenylpiperidines as Modulators of Cortical Catecholaminergic Neurotransmission | NSAB, FILIAL AF NEUROSEARCH SWEDEN AB, SVERIGE (DK) | 2008-10-30 | — | — | US | disclosed |
| EP-1963268-A1 | DISUBSTITUTED PHENYLPIPERIDINES AS MODULATORS OF CORTICAL CATECHOLAMINERGIC NEUROTRANSMISSION | Neurosearch Sweden AB (SE) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007065655-A1 | DISUBSTITUTED PHENYLPIPERIDINES AS MODULATORS OF CORTICAL CATECHOLAMINERGIC NEUROTRANSMISSION | NEUROSEARCH SWEDEN AB (SE) | 2007-06-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080269286-A1 | Disubstituted Phenylpiperidines as Modulators of Cortical Catecholaminergic Neurotransmission | SLC6A2, SLC18A2, PNMT | SLC6A2 1/4885SLC6A4 15/4885SLC6A3 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.