Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 2/20 | 0.46 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | KCNA5 | P22460 | 6/20 | 0.40 |
| ▸ | PIP4K2C | Q8TBX8 | 2/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 8/20 | 0.37 |
| ▸ | TGM2 | P21980 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2368555 | 0.95 | TNF (0.52) | TNFNOD1MAPK1KCNA5PIP4K2C | |
| SCHEMBL2369294 | 0.90 | TGM2 (0.36) | TNFNOD1MAPK1TGM2SMN1; SMN2 | |
| SCHEMBL3386697 | 0.87 | TNF (0.48) | TNFNOD1MAPK1KCNA5PIP4K2C | |
| SCHEMBL3384583 | 0.87 | CLK4 (0.41) | TNFNOD1MAPK1PIP4K2CALDH1A1 | |
| SCHEMBL2368417 | 0.86 | SMN1; SMN2 (0.37) | KCNA5PIP4K2CMAOBKCNH2SMN1; SMN2 | |
| SCHEMBL3415890 | 0.85 | ESR1 (0.40) | TNFNOD1MAPK1PIP4K2CSMN1; SMN2 | |
| SCHEMBL2368543 | 0.82 | TNF (0.56) | TNFNOD1MAPK1KCNA5PIP4K2C | |
| SCHEMBL2905196 | 0.80 | MAPK1 (0.44) | TNFNOD1MAPK1PIP4K2CMAOB | |
| SCHEMBL3415634 | 0.80 | KDM4E (0.39) | TNFNOD1MAPK1KCNA5PIP4K2C | |
| SCHEMBL2369260 | 0.80 | TNF (0.55) | TNFNOD1MAPK1KCNA5PIP4K2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1641803-B3 | THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS | XENTION LTD (GB) | 2010-12-08 | — | — | EP | disclosed |
| EP-1641803-B1 | THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS | XENTION LTD (GB) | 2009-03-18 | — | — | EP | disclosed |