Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KCNA5 | P22460 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | PRKCI | P41743 | 1/20 | 0.36 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.34 |
| ▸ | CXCR5 | P32302 | 1/20 | 0.34 |
| ▸ | APLNR | P35414 | 1/20 | 0.34 |
| ▸ | CCR6 | P51684 | 1/20 | 0.34 |
| ▸ | HMGCR | P04035 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | SCD | O00767 | 1/20 | 0.33 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.33 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3415634 | 0.95 | KDM4E (0.39) | SMN1; SMN2KDM4EALDH1A1MAPTKCNA5 | |
| SCHEMBL3384949 | 0.90 | BCL2 (0.33) | SMN1; SMN2KDM4EALDH1A1MAPTMEN1 | |
| Butane SCHEMBL6359344 | 0.89 | SMN1; SMN2 (0.41) | SMN1; SMN2KDM4EALDH1A1MAPTKCNA5 | |
| SCHEMBL2368411 | 0.88 | SMN1; SMN2 (0.42) | SMN1; SMN2KDM4EALDH1A1MAPTKCNA5 | |
| SCHEMBL3387551 | 0.87 | DYRK1A (0.40) | SMN1; SMN2KDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL3386708 | 0.86 | TNF (0.46) | SMN1; SMN2ALDH1A1KCNA5PIP4K2CMAOB | |
| SCHEMBL3386501 | 0.86 | PRKCI (0.36) | SMN1; SMN2KDM4EALDH1A1MAPTPRKCI | |
| SCHEMBL3415627 | 0.83 | ALDH1A1 (0.44) | SMN1; SMN2KDM4EALDH1A1MAPTKCNA5 | |
| SCHEMBL2368544 | 0.80 | KCNA5 (0.44) | SMN1; SMN2KCNA5MEN1KMT2APRKCI | |
| SCHEMBL2368555 | 0.80 | TNF (0.52) | SMN1; SMN2ALDH1A1KCNA5PIP4K2CKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8022076-B2 | Thieno[2,3-d]pyrimidine derivatives as potassium channel modulators; antiarrhythmia agents | XENTION LIMITED (GB) | 2011-09-20 | — | — | US | disclosed |
| EP-1641803-B3 | THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS | XENTION LTD (GB) | 2010-12-08 | — | — | EP | disclosed |
| EP-1641803-B1 | THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS | XENTION LTD (GB) | 2009-03-18 | — | — | EP | disclosed |
| EP-1641803-A1 | THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS | Xention Discovery Limited (GB) | 2006-04-05 | — | — | EP | disclosed |
| WO-2004111057-A1 | THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS | XENTION DISCOVERY LIMITED (GB) | 2004-12-23 | — | — | WO | disclosed |