Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIMK1 | P53667 | 2/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.33 |
| ▸ | KDR | P35968 | 3/20 | 0.33 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.33 |
| ▸ | LCK | P06239 | 2/20 | 0.33 |
| ▸ | CSF1R | P07333 | 2/20 | 0.33 |
| ▸ | FLT1 | P17948 | 2/20 | 0.33 |
| ▸ | CLK2 | P49760 | 2/20 | 0.33 |
| ▸ | BTK | Q06187 | 2/20 | 0.33 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.33 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.33 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.33 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.33 |
| ▸ | PLK4 | O00444 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
| ▸ | FES | P07332 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3386423 | 0.83 | MCL1 (0.41) | KDRKITTEK | |
| SCHEMBL3382775 | 0.81 | EGFR (0.36) | LIMK1FGFR1KDRPRKD3MAP4K4 | |
| SCHEMBL5792474 | 0.77 | PTGS1 (0.43) | MAPTALDH1A1L3MBTL1LMNAMEN1 | |
| SCHEMBL2368964 | 0.74 | MAPT (0.34) | LIMK1FGFR1KDRPRKD3MAP4K4 | |
| SCHEMBL3387014 | 0.71 | SMN1; SMN2 (0.60) | KDRMAPTNPSR1ALDH1A1L3MBTL1 | |
| SCHEMBL3384503 | 0.71 | MCL1 (0.36) | KDRCLK4NPSR1ALDH1A1GAA | |
| SCHEMBL14965012 | 0.71 | SMN1; SMN2 (0.42) | LIMK1FGFR1KDRPRKD3MAP4K4 | |
| SCHEMBL6359806 | 0.67 | SMN1; SMN2 (0.39) | LIMK1FGFR1MAPTALDH1A1HTT | |
| SCHEMBL3384558 | 0.67 | FGFR1 (0.46) | LIMK1FGFR1KDRMAPTALDH1A1 | |
| SCHEMBL3385441 | 0.66 | ALDH1A1 (0.53) | FGFR1KDRPRKD3MAP4K4LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1641803-B3 | THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS | XENTION LTD (GB) | 2010-12-08 | — | — | EP | disclosed |
| EP-1641803-B1 | THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS | XENTION LTD (GB) | 2009-03-18 | — | — | EP | disclosed |
| EP-1641803-A1 | THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS | Xention Discovery Limited (GB) | 2006-04-05 | — | — | EP | disclosed |
| WO-2004111057-A1 | THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS | XENTION DISCOVERY LIMITED (GB) | 2004-12-23 | — | — | WO | disclosed |