Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.50 |
| ▸ | NOS1 | P29475 | 1/20 | 0.50 |
| ▸ | NOS2 | P35228 | 1/20 | 0.50 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.47 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.46 |
| ▸ | CDK8 | P49336 | 1/20 | 0.46 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.43 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.42 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3388618 | 0.80 | TGFBR1 (0.48) | TGFBR1FLT3GSK3BPIK3CD | |
| SCHEMBL2860410 | 0.79 | LOXL2 (0.47) | NOS1NOS2ADRB2LOXL2 | |
| SCHEMBL31367022 | 0.79 | LOXL2 (0.47) | NOS1NOS2ADRB2LOXL2 | |
| SCHEMBL3791745 | 0.79 | LOXL2 (0.60) | NOS3NOS1NOS2CDK8TAAR1 | |
| SCHEMBL373685 | 0.78 | TGFBR1 (0.81) | TGFBR1 | |
| SCHEMBL29832157 | 0.78 | TGFBR1 (0.43) | NOS3NOS1NOS2TGFBR1FLT3 | |
| Hydrochloric Acid SCHEMBL28952754 | 0.77 | LOXL2 (0.45) | NOS1NOS2ADRB2LOXL2 | |
| SCHEMBL3794460 | 0.77 | TAAR1 (0.70) | NOS3NOS1NOS2ADRB2CDK8 | |
| SCHEMBL8337311 | 0.77 | NPC1 (0.52) | TGFBR1FLT3GSK3B | |
| SCHEMBL21788578 | 0.77 | MAP4K4 (0.56) | TGFBR1MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010052448-A2 | FUSED PYRAZINE DERIVATIVES AS KINASE INHIBITORS | UCB PHARMA S.A. (BE) | 2010-05-14 | — | — | WO | disclosed |