Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | HPGD | P15428 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | MME | P08473 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL769243 | 0.86 | ALDH1A1 (0.51) | ALDH1A1HPGDLMNATP53HTT | |
| SCHEMBL769244 | 0.86 | ALDH1A1 (0.51) | ALDH1A1HPGDLMNATP53HTT | |
| SCHEMBL13483598 | 0.81 | LMNA (0.56) | ALDH1A1HPGDLMNATP53HTT | |
| SCHEMBL3178518 | 0.80 | LMNA (0.55) | ALDH1A1HPGDLMNATP53HTT | |
| SCHEMBL3178511 | 0.80 | LMNA (0.55) | ALDH1A1HPGDLMNATP53HTT | |
| SCHEMBL18102721 | 0.77 | TDP1 (0.47) | ALDH1A1HPGDLMNAKDM4ERECQL | |
| SCHEMBL15375613 | 0.76 | HPGD (0.38) | HPGD | |
| SCHEMBL3649883 | 0.76 | ACACB (0.46) | LMNAHTTMEN1KMT2A | |
| SCHEMBL16847415 | 0.76 | RECQL (0.46) | ALDH1A1HPGDLMNATP53HTT | |
| SCHEMBL1186568 | 0.76 | HSD17B10 (0.59) | ALDH1A1HPGDLMNAKDM4ERECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010051373-A1 | CYCLOPROPANE AMIDES AND ANALOGS EXHIBITING ANTI-CANCER AND ANTI-PROLIFERATIVE ACTIVITIES | DECIPHERA PHARMACEUTICALS, LLC (US) | 2010-05-06 | — | — | WO | disclosed |