Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MGAM | O43451 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SI | P14410 | 1/20 | 0.36 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | PTGIR | P43119 | 3/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13496227 | 0.90 | KMT2A (0.37) | TSHRPOLBLMNAALDH1A1KMT2A | |
| SCHEMBL3254360 | 0.88 | KMT2A (0.44) | TSHRPOLBALDH1A1KMT2AMGAM | |
| SCHEMBL3248118 | 0.84 | KMT2A (0.49) | LMNAALDH1A1KMT2AL3MBTL1MGAM | |
| SCHEMBL3264372 | 0.83 | KMT2A (0.47) | LMNAALDH1A1KMT2AL3MBTL1MGAM | |
| SCHEMBL13496223 | 0.81 | KMT2A (0.38) | TSHRPOLBLMNAALDH1A1KMT2A | |
| SCHEMBL27055143 | 0.80 | RAB9A (0.46) | TSHRPOLBLMNAALDH1A1RAB9A | |
| SCHEMBL6517420 | 0.80 | PLG (0.39) | LMNAALDH1A1KMT2AMGAMGAA | |
| SCHEMBL6517416 | 0.80 | PLG (0.39) | LMNAALDH1A1KMT2AMGAMGAA | |
| SCHEMBL7009023 | 0.80 | KMT2A (0.39) | ALDH1A1KMT2AMGAMGAASI | |
| SCHEMBL534088 | 0.79 | TSHR (0.45) | TSHRPOLBLMNAALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010018132-A1 | COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2010-02-18 | — | — | WO | disclosed |
| WO-2010018132-A1 | COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2010-02-18 | — | — | WO | disclosed |