Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | DRD3 | P35462 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 2/20 | 0.41 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CCR3 | P51677 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3387874 | 0.92 | HRH3 (0.44) | HRH3 | |
| SCHEMBL3388747 | 0.85 | HRH3 (0.43) | HRH3 | |
| SCHEMBL3386153 | 0.83 | CHRM2 (0.45) | HRH3CHRM2MAPK14DRD2DRD3 | |
| SCHEMBL3387634 | 0.83 | HRH3 (0.44) | HRH3 | |
| SCHEMBL3388425 | 0.82 | HRH3 (0.52) | HRH3CHRM2MAPK14DRD2DRD3 | |
| SCHEMBL3390735 | 0.82 | KDM2B (0.45) | HRH3 | |
| SCHEMBL3390069 | 0.82 | HRH3 (0.50) | HRH3MAPK14KDM4EACHELMNA | |
| SCHEMBL3944012 | 0.81 | HRH3 (0.47) | HRH3ACHE | |
| SCHEMBL3388925 | 0.81 | HRH3 (0.45) | HRH3KDM4E | |
| SCHEMBL3948632 | 0.81 | HRH3 (0.47) | HRH3ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029534-B1 | 1H-INDOL-5-YL-PIPERAZIN-1-YL-METHANONE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2010-12-22 | — | — | EP | disclosed |