SCHEMBL338865

SCHEMBL338865

C[Si]1(CCc2ccccc2)CCCCO1

nearest known ligand 0.35

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
SLC6A3 Q01959 1/20 0.33
SIGMAR1 Q99720 2/20 0.33
POLB P06746 1/20 0.33
SLC18A2 Q05940 1/20 0.33
TAAR1 Q96RJ0 3/20 0.32
ATM Q13315 1/20 0.32
ALDH1A1 P00352 1/20 0.32
HPGD P15428 1/20 0.32
ALOX15 P16050 1/20 0.32
ALOX12 P18054 1/20 0.32
CASP1 P29466 1/20 0.32
HSD17B10 Q99714 1/20 0.32
KCNH2 Q12809 1/20 0.32
CYP2A6 P11509 1/20 0.31
HTR2A P28223 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
LOXL2 Q9Y4K0 1/20 0.31
TDP1 Q9NUW8 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9308520 0.83 TP53 (0.31) POLB
SCHEMBL13755964 0.81 SMN1; SMN2 (0.32) SMN1; SMN2
Benzylamine SCHEMBL16684744 0.80 LOXL2 (0.40) TAAR1LOXL2
SCHEMBL17048840 0.80 TAAR1 (0.40) SLC6A3TAAR1ALDH1A1KCNH2
SCHEMBL7057494 0.73
SCHEMBL2404033 0.71 TAAR1 (0.39) TAAR1ALDH1A1HPGD
SCHEMBL2853648 0.70
Ammonia Solution, Strong SCHEMBL28966876 0.69
SCHEMBL7650659 0.69
SCHEMBL4355743 0.68 CALM1 (0.31)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0187266-B1 SOLID SILICONE DEFOAMING AGENT AND METHOD FOR ITS PRODUCTION Toray Silicone Company Limited (JP) 1988-03-16 EP claimed
US-8097602-B1 Method of treating body insect infestation HOST PHARMACEUTICALS, LLC (US) 2012-01-17 US disclosed
CN-102306807-A Cathode of film-free air microbial fuel cell and manufacturing method thereof UNIV SOUTH CHINA TECH 2012-01-04 CN disclosed
US-6101636-A Sculptured helmet ornamentation WILLIAMS MARIX (US) 2000-08-15 US disclosed
EP-0757082-B1 Storage stable dispersions of finely divided solids in organosiloxane compositions DOW CORNING (US) 2000-05-17 EP disclosed
EP-0710704-B1 Curable silicone rubber composition DOW CORNING (US) 1999-11-24 EP disclosed
US-5874388-A LOW STATIC FRICTION GREASE COMPRISING BLEND OF A SILICONE OIL, POLYTETRAFLUOROETHYLENE POWDER, AND MELAMINE CYANURATE DOW CORNING CORPORATION (US) 1999-02-23 US disclosed
WO-1998023173-A1 SCULPTURED HELMET ORNAMENTATION WILLIAMS MARIX (US) 1998-06-04 WO disclosed
US-5679739-A PHENYLALKYLSILOXANE OLIGOMERS WHICH EXHIBIT LIMITED COMPATIBILITY WITH CROSSLINKABLE POLYORGANOSILOXANES DOW CORNING CORPORATION (US) 1997-10-21 US disclosed
EP-0757082-A2 Storage stable dispersions of finely divided solids in organosiloxane compositions DOW CORNING CORPORATION (US) 1997-02-05 EP disclosed
EP-0583775-B1 Slipping layer binder for dye-donor element used in thermal dye transfer EASTMAN KODAK CO (US) 1996-12-11 EP disclosed
US-5563197-A HOMOGENEITY THIXOTROPIC LIQUID, PASTE OR GEL; BLENDING DOW CORNING CORPORATION (US) 1996-10-08 US disclosed
US-5563210-A HOMOGENEITY THIXOTROPIC LIQUID, PASTE OR GEL; BLENDING;MOISTURE CURABLE DOW CORNING CORPORATION (US) 1996-10-08 US disclosed
EP-0731142-A2 Thixotropic organosiloxane compositions DOW CORNING CORPORATION (US) 1996-09-11 EP disclosed
US-5516832-A OF A POLYSILOXANE GUM, A REINFORCING FILLER, A POLYBUTYLENE AND A HYDROXY-TERMINATED POLYSILOXANE DOW CORNING CORPORATION (US) 1996-05-14 US disclosed
EP-0710704-A2 Curable silicone rubber composition DOW CORNING CORPORATION (US) 1996-05-08 EP disclosed
EP-0583775-A2 Slipping layer binder for dye-donor element used in thermal dye transfer EASTMAN KODAK COMPANY (US) 1994-02-23 EP disclosed
US-5240899-A Aminoalkyl(dialkysilyl)-terminated polydialkylsiloxane, polyvinyl acetal or formal EASTMAN KODAK COMPANY (US) 1993-08-31 US disclosed
US-4656221-A SOLVENT-FREE POLYSILOXANE COATINGS; RADIATION TRANSPARENT FOR USE ON COLORLESS BEVERAGE BOTTLES TOSHIBA SILICONE CO., LTD. (JP) 1987-04-07 US disclosed