Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 3/20 | 0.45 |
| ▸ | AURKA | O14965 | 2/20 | 0.45 |
| ▸ | CHUK | O15111 | 1/20 | 0.45 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.45 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.45 |
| ▸ | SYK | P43405 | 1/20 | 0.45 |
| ▸ | JAK3 | P52333 | 1/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.45 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.45 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 8/20 | 0.44 |
| ▸ | KMO | O15229 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | PRKACA | P17612 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13362628 | 0.83 | ROCK2 (0.64) | SLC2A1ROCK2 | |
| SCHEMBL13362791 | 0.80 | ROCK2 (0.67) | CAMKK2CDK2AURKACHUKPDPK1 | |
| SCHEMBL3356118 | 0.79 | ROCK2 (0.67) | ROCK2 | |
| SCHEMBL3383947 | 0.78 | MAPT (0.37) | CAMKK2MAP4K4GSK3B | |
| SCHEMBL13362879 | 0.74 | CCNK (0.52) | CHUKRPS6KB1KDRJAK3ROCK1 | |
| SCHEMBL13362720 | 0.73 | MAP4K4 (0.46) | CAMKK2CDK2AURKACHUKPDPK1 | |
| SCHEMBL3387260 | 0.72 | ROCK2 (0.58) | ROCK1PIM1ROCK2 | |
| SCHEMBL13362884 | 0.72 | JAK3 (0.50) | AURKACHUKRPS6KB1KDRJAK3 | |
| SCHEMBL15819555 | 0.70 | POLB (0.46) | — | |
| SCHEMBL14499937 | 0.70 | PIM1 (0.55) | CAMKK2CDK2AURKACHUKPDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010056758-A1 | QUINAZOLINE DERIVATIVES AS KINASE INHIBITORS | FENG YANGBO (US) | 2010-05-20 | — | — | WO | disclosed |
| WO-2010056758-A1 | QUINAZOLINE DERIVATIVES AS KINASE INHIBITORS | FENG YANGBO (US) | 2010-05-20 | — | — | WO | disclosed |