Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.34 |
| ▸ | MINK1 | Q8N4C8 | 4/20 | 0.34 |
| ▸ | TNIK | Q9UKE5 | 4/20 | 0.34 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.34 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
| ▸ | CAMKK1 | Q8N5S9 | 1/20 | 0.33 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.33 |
| ▸ | KHK | P50053 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3388822 | 0.78 | CAMKK2 (0.49) | MAP4K4CAMKK2GSK3B | |
| SCHEMBL3387260 | 0.74 | ROCK2 (0.58) | — | |
| SCHEMBL13362879 | 0.74 | CCNK (0.52) | MAP4K4 | |
| SCHEMBL15819555 | 0.72 | POLB (0.46) | — | |
| SCHEMBL13362884 | 0.72 | JAK3 (0.50) | MAP4K4AAK1TBK1GSK3B | |
| SCHEMBL17260211 | 0.69 | MTNR1A (0.57) | MAPT | |
| SCHEMBL13362782 | 0.69 | PRMT5 (0.47) | AAK1 | |
| SCHEMBL17376066 | 0.68 | ABL1 (0.39) | MAPTMAPK1 | |
| SCHEMBL13362810 | 0.67 | ROCK2 (0.60) | — | |
| SCHEMBL22068158 | 0.66 | IDO1 (0.55) | MAPTMAP4K4MINK1TNIKMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010056758-A1 | QUINAZOLINE DERIVATIVES AS KINASE INHIBITORS | FENG YANGBO (US) | 2010-05-20 | — | — | WO | disclosed |
| WO-2010056758-A1 | QUINAZOLINE DERIVATIVES AS KINASE INHIBITORS | FENG YANGBO (US) | 2010-05-20 | — | — | WO | disclosed |